Isomer Separation of Polybrominated Diphenyl Ether Metabolites using nanoESI-TIMS-MS.

Decabromodiphenyl ether in the rat: absorption, distribution, metabolism, and excretion.

Among the group of polybrominated diphenyl ethers used as flame-retardants, the fully brominated diphenyl ether, decabromodiphenyl ether (decaBDE), is the most commonly used. Despite the large usage of decaBDE, neither the metabolic pathways nor the absorption have been addressed, and there are very few studies on its toxicology. In this work, it is shown that after a single oral dose of 14C-la...

Analysis of Polybrominated Dephenyl Ether Flame Retardants by Gas Chromatography/Mass Spectrometry

Polybrominated diphenyl ethers (PBDEs), commonly used flame retardants, are under scrutiny as a result of their global presence and rapid bioaccumulation. Legislative and commercial groups have initiated programs to reduce or eliminate specific PBDE congeners as a result of their potential health threat. This application note will demonstrate a gas chromatography/mass spectrometry (GC/MS) analy...

Rapid determination of decabromodiphenyl ether in polystyrene by thermal desorption-GC/MS.

A rapid determination of decabromodiphenyl ether (DeBDE) in polystyrene (PS) by thermal desorption (TD)-GC/MS was studied. The TD-GC/MS method using a pyrolysis-GC/MS system allowed the quick quantification of DeBDE in a waste TV back plate composing of a PS flame-retarded with polybrominated diphenyl ethers on the basis of the resulting chromatogram with a ca. 4% relative standard deviation wi...

Measurement of Polybrominated Diphenyl Ethers and Metabolites in Mouse Plasma after Exposure to a Commercial Pentabromodiphenyl Ether Mixture

BACKGROUND Previous studies have shown that polybrominated diphenyl ethers (PBDEs) behave as weak estrogens in animal and cell culture bioassays. In vivo metabolites of PBDEs are suspected to cause these effects. OBJECTIVES To identify candidate metabolites, mouse plasma samples were collected after continuous oral and subcutaneous exposure to DE-71, a widely used commercial pentabromodipheny...

Potential chlorinated and brominated interferences on the polybrominated diphenyl ether determinations by GC-MS